2026 NFL Mock Draft 21-25: Eagles soar high with big wide receiver, 49ers land elite tackle/guard
No. 21: Buffalo Bills – Cashius Howell, ED, Texas A&M
The want here for the Buffalo Bills amongst fans will be a wide receiver. The need, however, is at edge. With the No. 21 overall pick in the 2026 NFL Draft, they select Texas A&M’s Cashius Howell to help with the pass rush, especially with Joey Bosa and AJ Epenesa entering free agency.
No. 22: Philadelphia Eagles – Denzel Boston, WR, Washington
Expect the A.J. Brown drama to spill into the offseason once again, especially if the Eagles have an early playoff exit. To replace him, the Eagles fly with Washington wide receiver Denzel Boston who is a big, physical receiver who will give them some of the playmaking ability of Brown. The 6-foot-4, 209-pound wide receiver is noted for his contested catch ability and route running, much like Brown.
No. 23: New York Jets via Indianapolis Colts – Brandon Cisse, CB, South Carolina
The Jets trade of Sauce Gardner is looking better and better. The Colts are starting to lose games, which mean the draft pick position is sweeter. With the No. 23 overall pick the Jets attempt to replace Garnder at cornerback with the selection of South Carolina’s Brandon Cisse. A fast corner with good size, Cisse is rising up the draft big board due to his impactful play in the secondary.
No. 24: San Francisco 49ers– Francis Mauigoa, T, Miami (FL)
The 49ers snag one of the top offensive linemen in the draft with Francis Mauigoa. The 49ers can address a few other needs here, but with Mauigoa falling into their lap decide to get stronger along the O-line and address their needs at edge and wide receiver on Day 2.
No. 25: Los Angeles Chargers – Olaivavega Ioane, G, Penn State
The Chargers lost their two top tackles to injury in 2025. With both Rashawn Slater and Joe Alt returning in 2026, the Chargers beef up on the line with the selection of Penn State’s Olaivavega Ioane who is a powerful guard in the interior of the line. Adding Ioane to the line will help the Chargers be more of a running team in 2026.